Monash University researchers have created one of the world’s largest collections of live tumors from prostate cancer patients, accelerating testing of new treatments for prostate cancer and resulting in greater benefit. fast for patients.
One of the most common cancers, prostate cancer is also one of the most difficult to study in the laboratory, with frequently used models derived more than 40 years ago. With the establishment of the Melbourne Urological Research Alliance (MURAL), hundreds of Victorian men generously donated samples of their cancerous tissue, allowing the team to study a wider variety of living tumors and test the effectiveness of a wider variety of therapies for their ability to stop tumor growth.
The PDX (patient-derived xenografts) collection, developed by a multidisciplinary consortium and led by Professor Gail Risbridger and Associate Professor Renea Taylor at the Monash Biomedicine Discovery Institute (BDI), now includes 59 tumors, collected from 30 patients between 2012- 2020 and today is one of the largest collections of prostate cancer models in the world.
The full characterization of the PDX collection is published in Nature Communication.
MURAL PDXs are a sustainable resource of novel cancer models that can be shared with other academic researchers or pharmaceutical companies. Patients and their families are directly integrated into this endeavor, including the EJ Whitten Foundation which has played a pivotal role over the past 10 years by providing over $ 1 million in donations allowing this resource to be developed and on the agenda of being at the forefront of the international community. field.
“This project begins and ends with patients like EJ Whitten. We take tissue from patients – do laboratory tests – and the findings then advance the treatment of patients,” said Professor Risbridger. “Our new models of prostate cancer have aroused the interest of scientists and the pharmaceutical industry around the world.”
Ted Whitten, Executive Director and Founder of the EJWhitten Foundation, congratulates the Monash University Biomedicine Discovery Institute for its recent findings in prostate cancer research. “We believe Monash University is a leader in prostate cancer research and we are delighted to have been able to financially support many of their important programs over the past ten years.”
Dr Mitchell Lawrence, also of Monash BDI and lead author, said: “This resource provides an opportunity to link molecular changes in prostate cancer to pathology, to cultivate organoids and to test functional responses to therapies, which have rarely been applied to prostate cancer. given the lack of suitable models. ”
Experts unite to eradicate prostate cancer
Gail P. Risbridger et al, The MURAL collection of xenografts derived from prostate cancer patients enables discovery through preclinical models of uro-oncology, Nature Communication (2021). DOI: 10.1038 / s41467-021-25175-5
Provided by Monash University
Quote: Patients Helping Researchers Advance Prostate Cancer Treatments (2021, 23 Aug) Retrieved 23 Aug 2021 from https://medicalxpress.com/news/2021-08-patients-advance-treatments-prostate-cancer .html
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